---
product_id: 3558979
title: "Doctor's Best SAM-e 400 mg, Vegan, Gluten Free, Soy Free, Mood and Joint Support, 60 Enteric Coated Tablets"
brand: "doctor's best"
price: "₪281"
currency: ILS
in_stock: true
reviews_count: 8
category: "Doctor's Best"
url: https://www.desertcart.co.il/products/3558979-doctors-best-sam-e-400-mg-vegan-gluten-free-soy
store_origin: IL
region: Israel
---

# Vegan, Gluten & Soy Free purity 400 mg potent SAMe per tablet Supports mood, joints & liver Doctor's Best SAM-e 400 mg, Vegan, Gluten Free, Soy Free, Mood and Joint Support, 60 Enteric Coated Tablets

**Brand:** doctor's best
**Price:** ₪281
**Availability:** ✅ In Stock

## Summary

> 💼 Elevate your mind, move with ease, and detox like a pro—SAMe your way to peak performance!

## Quick Answers

- **What is this?** Doctor's Best SAM-e 400 mg, Vegan, Gluten Free, Soy Free, Mood and Joint Support, 60 Enteric Coated Tablets by doctor's best
- **How much does it cost?** ₪281 with free shipping
- **Is it available?** Yes, in stock and ready to ship
- **Where can I buy it?** [www.desertcart.co.il](https://www.desertcart.co.il/products/3558979-doctors-best-sam-e-400-mg-vegan-gluten-free-soy)

## Best For

- doctor's best enthusiasts

## Why This Product

- Trusted doctor's best brand quality
- Free international shipping included
- Worldwide delivery with tracking
- 15-day hassle-free returns

## Key Features

- • **Multi-System Support:** Enhances neurotransmitter synthesis for mood, promotes joint comfort and mobility, and boosts liver detoxification.
- • **Clean & Conscious Formula:** Vegan, gluten-free, and soy-free—crafted for the mindful professional who demands purity without compromise.
- • **Clinically Proven Double Strength:** 400 mg of pharmaceutical-grade SAMe delivers maximum bioactive S,S isomer for superior mood and joint support.
- • **Trusted Quality Backed by Science:** Over 40 years and 18 controlled human trials validate SAMe’s effectiveness—join thousands who rely on proven results.
- • **Enteric Coated for Optimal Absorption:** Special coating protects SAMe from stomach acid, ensuring maximum potency and minimizing digestive discomfort.

## Overview

Doctor's Best SAM-e 400 mg offers a high-potency, pharmaceutical-grade supplement featuring the active S,S isomer of SAMe, clinically proven to support mood enhancement, joint comfort, and liver detoxification. This vegan, gluten-free, and soy-free formula uses enteric-coated tablets to maximize absorption and minimize stomach upset, backed by over 40 years of scientific research and trusted by thousands seeking natural cognitive and physical wellness.

## Description

SAMe 400 contains 400 mg of active SAMe in each tablet. Doctor's Best utilizes only the highest quality Italian SAMe available on the market. This ensures that you receive the most potent SAMe product with the highest percentage of the active S,S form per serving, bar none. S-Adenosyl Methionine (SAMe) is derived from the amino acid methionine and is one of the most important methyl donors in the central nervous system. Methylation (donation of methyl groups) is an essential process in ensuring the proper function of a number of organ systems. SAMe is involved in numerous biochemical reactions in tissue including the liver, joints and brain. SAMe is also required for the biosynthesis of critical neurotransmitters and hormones. The manufacturing process of SAMe yields two forms, the S,S and the R,S isomers. The S,S isomer is the active form that mediates biochemical activity in the human body, whereas the R,S form is considered to be biologically inactive. The Italian SAMe used in Double-Strength SAMe 400 is processed to yield the highest available percentage of the active pure S,S form on the market. SAMe may enhance cartilage protection and promote the synthesis of proteoglycans, essential components of connective tissue. Clinical studies show an ability of SAMe to enhance mobility and movement, and promote joint comfort.* SAMe-catalyzed methylation reactions promote the synthesis of neurotransmitters, which have the potential to promote enhanced mood. SAMe may also upregulate the production of phosphatidylcholine, supporting cognitive function.* SAMe enhances liver synthesis of glutathione, an antioxidant. Glutathione promotes detoxification and liver protection. Studies show SAMe may protect liver tissue from injury caused by a number of toxins.*

Review: Works well for joint pain and mild depression - I tried a different brand of SAM-E about a year ago. Began having stomach cramps soon after. Tried Doctors Best and found I no longer had stomach issues. I suffer from joint pain in the legs and mild depression. Noticed a major relief in joint pain and a better state of mind with a reduction in my depression. I buy a 60-count box once a month. 2 tabs a day. While I would like to double the daily intake, forty dollars a month is the most I can afford. My honest opinion, it relieves joint pain, and puts me in a better state of mind, without getting into SSRI's or opiates. The only minus is the price.
Review: Good Quality for Price - I used this product on my veterinarian's recommendation, for my 17 year old dog who was losing his step and acting a little grumpy. Along with pain meds, this really made a difference I felt. I decided to try it myself and I was surprised when I seemed to feel my usual winter blues, so much less severely. Be aware that it takes a couple MONTHS to feel a noticeable difference. But, your body needs this anyway so it certainly will do no harm to try it. Always let your doctor and/or pharmacist know you're on it though. There's some moderate interactions mostly of the "makes this medicine slightly less effective" variety. Always look for SAM-e with the foil blister pac and make sure you're giving it without food. It's sensitive to light, heat, and moisture. I've tried a few brands and right now Doctor's Best strikes the sweet spot between reliable quality and price. This is one supplement that you really HAVE to pay for effectiveness.

## Features

- Doctor's Best SAMe Double Strength is proven to enhance mood and promote cognitive health
- SAMe is essential for the healthy metabolism of the major brain transmitters dopamine, serotonin and norepinephrine
- SAMe has been proven to promote joint comfort and mobility and supports liver health and detoxification
- SAMe's effectiveness has been proven with 18 controlled human trials published over 40 years
- Pharmaceutical grade, Non-GMO, Gluten Free, Vegan

## Technical Specifications

| Specification | Value |
|---------------|-------|
| ASIN | B004YLAXOE |
| Age Range Description | Adult |
| Allergen Information | Gluten Free, Soy Free |
| Best Sellers Rank | #18,938 in Health & Household ( See Top 100 in Health & Household ) #565 in Blended Vitamin & Mineral Supplements #1,677 in Sales & Deals #1,751 in Diet & Sports Nutrition |
| Brand | Doctor's BEST |
| Brand Name | Doctor's BEST |
| Color | No Color |
| Container Type | Bottle |
| Customer Reviews | 4.6 out of 5 stars 3,473 Reviews |
| Diet Type | Gluten Free, Vegan |
| Dosage Form | Tablets |
| Flavor | Unflavored |
| Global Trade Identification Number | 00753950002524 |
| Item Dimensions | 3.25 x 2 x 6.13 inches |
| Item Form | Tablet |
| Item Height | 6.13 inches |
| Item Weight | 3.2 ounces |
| Manufacturer | Doctor’s Best, Inc |
| Material Features | Vegan |
| Material Type Free | Gluten Free / Soy Free |
| Model Name | SAM-e 400mg |
| Number of Items | 1 |
| Primary Supplement Type | multivitamin |
| Product Benefits | Detoxing |
| Special Ingredients | Amino Acid |
| Specific Uses For Product | Joint Relief |
| Total Servings Per Container | 60 |
| UPC | 753950002524 367157342781 |
| Unit Count | 60 Count |

## Product Details

- **Brand:** Doctor's BEST
- **Flavor:** Unflavored
- **Primary Supplement Type:** multivitamin
- **Unit Count:** 60 Count
- **Item Form:** Tablet
- **Item Weight:** 3.2 ounces
- **Item dimensions L x W x H:** 3.25 x 2 x 6.13 inches
- **Special Ingredients:** Amino Acid
- **Diet Type:** Gluten Free, Vegan
- **Product Benefits:** Detoxing

## Images

![Doctor's Best SAM-e 400 mg, Vegan, Gluten Free, Soy Free, Mood and Joint Support, 60 Enteric Coated Tablets - Image 1](https://m.media-amazon.com/images/I/61qTxsnqhPL.jpg)

## Available Options

This product comes in different **Size, Flavor** options.

## Questions & Answers

**Q: Is each tablet packaged in foil?**
A: The tablets are in a ten count foil blister pack. Each pill has it's own sealed compartment. I am an RN and this is like medical grade packaging. Safe.

**Q: Could this cause you to feel warm or hot and sometimes dizziness?**
A: SAM-e, especially when combined with other medications, has a potential to contribute to Seratonin Syndrome, which can cause temperature disregulation and dizziness. This is a supplement that effects the function of your brain and neural pathways. Please make sure you use it as directed and preferrably under the care of someone who is knowledgeable on the subject if you have not done your own research. If any adverse reactions occur, stop taking the supplement and please talk to your doctor about it. There is the potential for very bad reactions if Seratonin builds up too much. 

Every person's brain is unique and will react in different ways. Nothing involved in brain support supplements are a one-size-fits-all.

**Q: how long does it take to start working**
A: I have taken SAM-e for 15 years very successfully. It has never failed to work for me, unlike Rx antidepressants and other supplements (like St John's Wort). In the last year I have increased from 1 400 mg pill daily to 2. I'm in my 60s and i just seem to feel better with more. (It is also anti-aging because it helps correct the mistakes that accumulate in our DNA). In my experience SAM-e works very quickly. If I need a boost, I take an extra dose and I feel better within 1-2 hours. You can take up to 1600 mg in a day (four 400 mg pills) with no problem. If I know I'm going to have a stressful day I will head off problems by taking 2 upon awakening, and then 1-2 more later in the day, when I can be sure of an empty stomach. It's important to take SAM-e at least 30 minutes before food, or 2 hours after, for best absorption.

**Q: How do these compare to nature made? That's my usual.**
A: For me, I like Nature Made so much better. Nature Made worked for my husband and I. We switched to these in an effort to save money and within two weeks of the switch we both started hurting again. Also these came with several of the bubbles punctured and the pills were different colors, within the pack. If you read some of the recent reviews, you’ll see others had some of the same issues and far as punctured blister packs and color changes within the box. We switched back to Nature Made, which was the brand our Orthapedic doctor had recommended.

## Customer Reviews

### ⭐⭐⭐⭐⭐ Works well for joint pain and mild depression
*by A***R on August 23, 2025*

I tried a different brand of SAM-E about a year ago. Began having stomach cramps soon after. Tried Doctors Best and found I no longer had stomach issues. I suffer from joint pain in the legs and mild depression. Noticed a major relief in joint pain and a better state of mind with a reduction in my depression. I buy a 60-count box once a month. 2 tabs a day. While I would like to double the daily intake, forty dollars a month is the most I can afford. My honest opinion, it relieves joint pain, and puts me in a better state of mind, without getting into SSRI's or opiates. The only minus is the price.

### ⭐⭐⭐⭐⭐ Good Quality for Price
*by R***E on September 21, 2025*

I used this product on my veterinarian's recommendation, for my 17 year old dog who was losing his step and acting a little grumpy. Along with pain meds, this really made a difference I felt. I decided to try it myself and I was surprised when I seemed to feel my usual winter blues, so much less severely. Be aware that it takes a couple MONTHS to feel a noticeable difference. But, your body needs this anyway so it certainly will do no harm to try it. Always let your doctor and/or pharmacist know you're on it though. There's some moderate interactions mostly of the "makes this medicine slightly less effective" variety. Always look for SAM-e with the foil blister pac and make sure you're giving it without food. It's sensitive to light, heat, and moisture. I've tried a few brands and right now Doctor's Best strikes the sweet spot between reliable quality and price. This is one supplement that you really HAVE to pay for effectiveness.

### ⭐⭐⭐⭐⭐ It all depends on your body's needs
*by F***T on July 4, 2017*

I've been living with chronic back pain and several other chronic conditions for the past decade. My daughter has some of the same issues, and she recently found a Dr that determined what was wrong and prescribed a treatment program that made her much better. At her urging, I went to see her Dr, who put me through the Walsh Protocol screening. The blood test showed that I have the same problem my daughter has - a genetic defect called Undermethylation. As I understand it, the first indication of this condition is the histamine level in your blood. A normal person should score between 20 and 60, with 40 being average. My score was 79, which indicates a severe problem. My Dr is prescribing a rigorous program to address my issues, but she started me on SAM-e the day she got my test scores. I took my first dose right after waking up the next day, and within 10 minutes I could tell that I was feeling better. For the first time in my life, I am truly able to relax. I've been taking it 10 days now and feel much better in so many ways. A lifetime of tight muscles is not going to be corrected overnight, but for the first time in years I feel like I have hope of getting better. If you are considering trying this, I'd recommend you look up Undermethylation and see if you have the symptoms. I think it's extremely important for people to understand that SAM-e is probably not going to help you unless you have a high histamine score. If you have a score below 20, then you have the opposite condition - Overmethylation. If you have this, it's likely that SAM-e will make you worse. I believe this is the reason we see reviews all over the place, with some declaring it a great supplement and others saying it's worthless. It all depends on your body and what you need. In my case, there is no doubt that I inherited the disorder from my mother. She had many of the same symptoms. I told one of her brothers about SAM-e and he declared it a miracle after just 3 days of use. I hope that my review will prove helpful if you are considering trying SAM-e

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*Product available on Desertcart Israel*
*Store origin: IL*
*Last updated: 2026-01-29*