---
product_id: 2494120
title: "THORNE - 5-MTHF - Methylfolate (Active B9 Folate) Supplement - Supports Cardiovascular Health, Fetal Development, Nerve Health, Methylation & Homocysteine Levels* - 60 Servings - 5-MTHF 1mg"
brand: "thorne"
price: "₪146"
currency: ILS
in_stock: true
reviews_count: 10
category: "Thorne"
url: https://www.desertcart.co.il/products/2494120-thorne-5-mthf-methylfolate-active-b9-folate-supplement-supports-cardiovascular
store_origin: IL
region: Israel
---

# 4 rounds purity testing 1mg bioactive methylfolate supports cardiovascular & nerve health THORNE - 5-MTHF - Methylfolate (Active B9 Folate) Supplement - Supports Cardiovascular Health, Fetal Development, Nerve Health, Methylation & Homocysteine Levels* - 60 Servings - 5-MTHF 1mg

**Brand:** thorne
**Price:** ₪146
**Availability:** ✅ In Stock

## Summary

> 🧬 Elevate your health game with the active folate that professionals trust!

## Quick Answers

- **What is this?** THORNE - 5-MTHF - Methylfolate (Active B9 Folate) Supplement - Supports Cardiovascular Health, Fetal Development, Nerve Health, Methylation & Homocysteine Levels* - 60 Servings - 5-MTHF 1mg by thorne
- **How much does it cost?** ₪146 with free shipping
- **Is it available?** Yes, in stock and ready to ship
- **Where can I buy it?** [www.desertcart.co.il](https://www.desertcart.co.il/products/2494120-thorne-5-mthf-methylfolate-active-b9-folate-supplement-supports-cardiovascular)

## Best For

- thorne enthusiasts

## Why This Product

- Trusted thorne brand quality
- Free international shipping included
- Worldwide delivery with tracking
- 15-day hassle-free returns

## Key Features

- • **Elite Athlete Approved:** Chosen by 100+ pro sports teams and top healthcare practitioners for peak performance and wellness.
- • **Clinically Trusted Purity:** Backed by 4 rigorous lab tests ensuring unmatched quality and zero fillers.
- • **Neuro & Mood Optimization:** Enhances neurotransmitter production for sharper focus, balanced mood, and restful sleep.
- • **Pregnancy & Heart Support:** Clinically formulated to support fetal brain development and maintain healthy homocysteine levels.
- • **Precision Methylation Boost:** Unlock your body's methylation cycle with 1mg of active 5-MTHF for superior bioavailability.

## Overview

Thorne 5-MTHF delivers 1mg of bioactive methylfolate per serving, supporting methylation, cardiovascular health, nerve function, and fetal development. With 4 rounds of rigorous testing and a clean, filler-free formula, it’s the #1 recommended clinical brand trusted by healthcare pros and elite athletes alike.

## Description

Buy THORNE - 5-MTHF - Methylfolate (Active B9 Folate) Supplement - Supports Cardiovascular Health, Fetal Development, Nerve Health, Methylation & Homocysteine Levels* - 60 Servings - 5-MTHF 1mg on desertcart.com ✓ FREE SHIPPING on qualified orders

Review: Excellent Bioavailability with Noticeable Health Benefits - I started taking Thorne 5-MTHF after genetic testing revealed I have MTHFR mutations that affect my body's ability to process regular folic acid. My functional medicine doctor specifically recommended this Thorne product for its superior quality and bioavailable form of folate, and I've been consistently impressed with both the product quality and the health improvements I've experienced. What sets this supplement apart is the methylated form of folate, which bypasses the genetic conversion issues that affect many people. Within a few weeks of starting this supplement, I noticed improvements in my energy levels and overall sense of well-being that I hadn't experienced with regular B-vitamin complexes. My follow-up lab work showed significant improvement in my homocysteine levels, which was exactly what my doctor was hoping to achieve. The quality control and purity that Thorne is known for is evident in this product. The capsules are clean with no unnecessary fillers or artificial ingredients, and I've experienced no digestive upset or side effects. The dosing is appropriate and easy to incorporate into my daily supplement routine. The cardiovascular and neurological support benefits align perfectly with what my healthcare provider explained about methylfolate's role in cellular function. I feel confident knowing this is supporting my body's methylation processes that are crucial for so many aspects of health. The packaging protects the supplements well, and the expiration dates are always well into the future, indicating proper storage and handling. Highly recommend for anyone needing bioavailable folate, especially those with MTHFR mutations - excellent quality from a trusted brand that healthcare providers consistently recommend.
Review: High-Quality Active Folate That Makes a Noticeable Difference - I've been taking these for several months now, primarily because I have the MTHFR gene variation that makes it hard to process regular folic acid. Pros: -Bioavailability: Unlike synthetic folic acid, this is already in the methylated form, so my body can use it directly. I've noticed improved energy levels, better mood stability, and less of the "foggy" feeling I used to live with. -Purity & Quality: Thorne is known for third-party testing and minimal fillers, just cellulose capsule and the active ingredients. No gluten, dairy, or unnecessary additives. Perfect for people with sensitivities. -Supports Key Areas: It's great for methylation support, homocysteine regulation, nerve health, and overall cardiovascular wellness. -Easy to Take: Super small capsules, 60 per bottle (2-month supply at 1 per day), no taste or aftertaste. Cons (very minor): It's premium-priced compared to generic folic acid supplements, but you get what you pay for in terms of purity and effectiveness. If you're new to methylfolate, start slow, some people experience mild overstimulation at first (I didn't, but it's common advice). This has become a non-negotiable in my daily stack. If you need active B9 folate, Thorne's 5-MTHF is top-tier. Highly recommend! ⭐⭐⭐⭐⭐

## Features

- Healthy Methylation: Provides essential nutritional support in the form of bioactive, methylated folate (vitamin B9) to support the body's methylation cycle*
- Cognitive Support: Enhances the production of key neurotransmitters like serotonin, melatonin, dopamine, and other natural brain chemicals that regulate brain function and mood*
- Nerves & Circulation: Supports healthy blood vessel and nerve function, and supports healthy fetal brain development during pregnancy*
- 4 Rounds of Testing: Our state-of-the-art laboratories enable us to conduct 4 rounds of testing on every product, from analyzing the purity of raw materials to confirming the shelf life of finished formulas
- Trusted: Thorne is chosen by champions and trusted by 100+ professional sports teams, a proud partner of U.S. National Teams, and the #1 recommended clinical brand by health-care practitioners (2023 Health-Care Practitioner Seller Survey)

## Technical Specifications

| Specification | Value |
|---------------|-------|
| ASIN  | B00FY8IQ7C |
| Best Sellers Rank | #2,342 in Health & Household ( See Top 100 in Health & Household ) #2 in Vitamin B9 (Folic Acid) Supplements |
| Customer Reviews | 4.7 4.7 out of 5 stars (3,811) |
| Date First Available  | December 10, 2007 |
| Is Discontinued By Manufacturer  | No |
| Item model number  | B129 |
| Manufacturer  | Thorne Research |

## Product Details

- **Brand:** THORNE
- **Diet Type:** Gluten Free
- **Flavor:** Unflavored
- **Item Form:** Capsule
- **Primary Supplement Type:** Vitamin-b

## Images

![THORNE - 5-MTHF - Methylfolate (Active B9 Folate) Supplement - Supports Cardiovascular Health, Fetal Development, Nerve Health, Methylation & Homocysteine Levels* - 60 Servings - 5-MTHF 1mg - Image 1](https://m.media-amazon.com/images/I/71wLckVqoTL.jpg)

## Questions & Answers

**Q: What's the difference between this product and just a plain folate product?**
A: This product is methylated. That means that those individuals who have the genetic defect MTHFR will be able to use the folate and other B vitamins. These will be absorbed into their systems to keep homocysteine levels low among other benefits. If you don't have that defect, you do not need the methylation. Some of us will use it as long as we live.

**Q: Hi,  Can't purchase without viewing the Ingredient Label.  Could you post an image? Thank You.**
A: Hello MariaThorne Research 5-MTHF , on one capsule contains:Folate (as L-5-Methyltetrahydrofolate*) 1 mg.Other Ingredients: Microcrystalline Cellulose, Hypromellose (derived from cellulose) capsule, Leucine, Silicon Dioxide.  Until we can upload it on the list, here is a capture of it: http://ecx.images-amazon.com/images/I/81uj6EAFjZL._SL1500_.jpg The Febstore Team

**Q: What is the difference, if any, between Methyltetrahydrofolate and Methylfolate?**
A: The 5-MTHF, also known as L-methyl folate, methyltetrahydrofolate The brand is ExtraFolate-S, by Gnosis.
•        It’s the active form of folate and only the active L (aka S) form (not a racemic mixture of R and S)
•        Stabilized by calcium
•        The extraction process separates the active (S, aka L) isomer without using a solvent
•        Created by Gnosis, the technology leader in active folate supplementation
•        Contains only the L isomer (the active isomer) of 5-MTHF

Thorne's other formulas, such as the Methyl-Guard use a different form, it is still 5- MTHF, methyl folate, methyltetrahydrofolate but the brand is Quatrefolic, also provided by Gnosis. 
•        It’s the active form of folate and only the active L (aka S) form (not a racemic mixture of R and S)
•        Stabilized by glucosamine (not derived from shellfish).
•        This form passes the gastric barrier and is absorbed mainly in the small intestine by a carrier-mediated mechanism, which ensures higher folate uptake 
•        Created by Gnosis, the technology leader in active folate supplementation
•        Contains only the active L-isomer form of 5-MTHF
The difference is that one is a calcium salt and the other is a glucosamine salt. Overall, both are highly absorbable and providing 5-MTHF.

**Q: Newest bottles (November 2014) are smaller as are the capsules, much smaller. The product info looks the same. Is this the same stuff?**
A: Yes

## Customer Reviews

### ⭐⭐⭐⭐⭐ Excellent Bioavailability with Noticeable Health Benefits
*by A***S on November 27, 2025*

I started taking Thorne 5-MTHF after genetic testing revealed I have MTHFR mutations that affect my body's ability to process regular folic acid. My functional medicine doctor specifically recommended this Thorne product for its superior quality and bioavailable form of folate, and I've been consistently impressed with both the product quality and the health improvements I've experienced. What sets this supplement apart is the methylated form of folate, which bypasses the genetic conversion issues that affect many people. Within a few weeks of starting this supplement, I noticed improvements in my energy levels and overall sense of well-being that I hadn't experienced with regular B-vitamin complexes. My follow-up lab work showed significant improvement in my homocysteine levels, which was exactly what my doctor was hoping to achieve. The quality control and purity that Thorne is known for is evident in this product. The capsules are clean with no unnecessary fillers or artificial ingredients, and I've experienced no digestive upset or side effects. The dosing is appropriate and easy to incorporate into my daily supplement routine. The cardiovascular and neurological support benefits align perfectly with what my healthcare provider explained about methylfolate's role in cellular function. I feel confident knowing this is supporting my body's methylation processes that are crucial for so many aspects of health. The packaging protects the supplements well, and the expiration dates are always well into the future, indicating proper storage and handling. Highly recommend for anyone needing bioavailable folate, especially those with MTHFR mutations - excellent quality from a trusted brand that healthcare providers consistently recommend.

### ⭐⭐⭐⭐⭐ High-Quality Active Folate That Makes a Noticeable Difference
*by C***A on December 30, 2025*

I've been taking these for several months now, primarily because I have the MTHFR gene variation that makes it hard to process regular folic acid. Pros: -Bioavailability: Unlike synthetic folic acid, this is already in the methylated form, so my body can use it directly. I've noticed improved energy levels, better mood stability, and less of the "foggy" feeling I used to live with. -Purity & Quality: Thorne is known for third-party testing and minimal fillers, just cellulose capsule and the active ingredients. No gluten, dairy, or unnecessary additives. Perfect for people with sensitivities. -Supports Key Areas: It's great for methylation support, homocysteine regulation, nerve health, and overall cardiovascular wellness. -Easy to Take: Super small capsules, 60 per bottle (2-month supply at 1 per day), no taste or aftertaste. Cons (very minor): It's premium-priced compared to generic folic acid supplements, but you get what you pay for in terms of purity and effectiveness. If you're new to methylfolate, start slow, some people experience mild overstimulation at first (I didn't, but it's common advice). This has become a non-negotiable in my daily stack. If you need active B9 folate, Thorne's 5-MTHF is top-tier. Highly recommend! ⭐⭐⭐⭐⭐

### ⭐⭐⭐⭐⭐ Good product worked well with other products
*by D***E on February 5, 2026*

I think it's a good product, I have been feeling better after running through the first bottle and my labs have improved but I can't attribute improved labs to this product alone as I have been taking other medical grade supplements, meds and eating 90% red meat diet. I can safely buy again, it's just a little too pricy to keep it going.

## Frequently Bought Together

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*Product available on Desertcart Israel*
*Store origin: IL*
*Last updated: 2026-02-09*