

🐾 Stay ahead of pests with FRONTLINE Plus — because your dog deserves the best defense.
FRONTLINE Plus Flea and Tick Treatment for Large Dogs (45-88 lbs) delivers fast-acting, waterproof protection that kills fleas, flea eggs, larvae, chewing lice, and ticks for a full 30 days. Featuring active ingredients fipronil and (S)-methoprene, it breaks the flea life cycle and is trusted by pet owners for over 20 years. Easy to apply and suitable for puppies 8 weeks and older, this topical treatment ensures your dog stays comfortable and pest-free month after month.


















| Active Ingredients | fipronil and (S)-methoprene |
| Brand | Frontline |
| Customer Reviews | 4.4 out of 5 stars 49,630 Reviews |
| Item Form | Liquid |
| Item Volume | 339 Milliliters |
| Item Weight | 0.04 Pounds |
| Scent | Unscented |
R**Z
Finally found something that actually works!
After trying at least four different flea treatments that barely made a dent, I'm so relieved to have found these drops. They actually work - and work fast. We have two dogs who love being outside, and fleas have been an ongoing battle, especially during the warmer months. Within 24 hours of applying these drops, I noticed a huge difference. The scratching stopped, and when I checked them over, the fleas were gone. It's been several weeks now and still no sign of them coming back. Application is easy - just part the fur at the back of the neck and squeeze the tube. My dogs don't seem bothered by it at all, and it dries quickly so they can go about their day. The protection lasts the full month as advertised, which is more than I can say for some of the other brands we've tried. I've set up a subscription so I never run out because I'm not going back to the constant scratching and discomfort my pups were dealing with before. If you've been struggling to find an effective flea treatment, I highly recommend giving these a try. They've been a game-changer for us. Worth every penny for the peace of mind and happy, comfortable dogs!
E**1
Works good
Works good. Been using for 4-5 years. My German shepherd has no problems with its use. No stinking smell. Effective my dog doesn’t scratch. Easy to apply. Recommended
M**A
This stuff works!
This product gets the job done! My dogs have never had a flea or a tick while using this treatment. It's an excellent preventative. I've tried other treatments that just don't work, and I always come back to Frontline. It's easy to use. It is a little greasy when you first put it on, but that's to be expected, and it dries up by the next day.
K**E
May have worked
I think may have worked for my dogs . The only thing I have a complaint about is that the treatment itself is not enough I have two dogs and I had to use all three of these on them from between their shoulder blades to their tail. I’ve haven’t seen any fleas on them since using this but I’m not sure .
A**D
Frontline Defense
Works very well. Buying a lesser off brand or generic brand isn't worth it. Frontline is the best. Caution: make sure to buy the proper dose for your dog according to their weight. It is better &, safer to under dose and underestimate than to ever estimate. If your dog as a tick infestation you will have to remove the dead ticks with a tick removal device & bathe the dog afterwards. Their product is worth every penny & more. Don't waste your money on Genetic substitutions in in this case. Keeps dog & companion animals happy & healthy
L**N
Frontline plus flea and tick treatment for dogs
This works great! I have used it for years. I have tried other brands but they don't compare. Easy to use and does not have a horrible smell. Much better than flea and tick collars too
S**L
Didn't prevent fleas but Seresto collar did
The Frontline Plus flea and tick control for 45 to 88 pound dogs was worse than a disappointment. My dog is 50 pounds--well within the dosage range and become infested with fleas during the second month/dosage of usage. I'm not sure if the preventative actually worked the first month or if I just didn't notice the fleas until the fleas had multiplied enough for me to easily see them. I also don't know if I received the same quailty Frontline product through Amazon as a store/vet purchase. I have no reason to think that this was an imitation product other than some suspicions by other reviewers. Regardless, I had to use a flea dip and flea bomb my house. Once an infestation occurs, getting rid of the fleas is quite an aggravation. I'm trying Advantage II from PetSmart now to see if that will work. Hopefully, something will. June 24 2013, Advantage II didn't work either. I've had acceptable success from Certifect which I buy from my vet. I've used Certifect for over a year now. These flea and tick drops are made by Frontline but are only sold by prescription or thru a vetinarian. It works great for ticks. I've not had any problems with ticks from the first dosage. For a few days, though, after the dosage, he is a bit lethargic. However, my dog will still pick up fleas. The drops do kill the fleas but don't repel them quickly enough. Many people are having trouble with fleas because of the sucession of mild winters. The flea population isn't culled enough. During the summer months, the fleas just seem to overwhelm the medication and flea dips or additional organic sprays are necessary. I've been told that a new flea and tick pill may now be available. I know the flea pill works but I hadn't used it because I needed something for ticks. If this rumor is true, I'll definately give the pill a try. December 30, 2014. I finally found something that actually works for controlling fleas and ticks for my now 70 pound Labrador/mix. (He was a stray that my family adopted--short hair.) My vet introduced me to a new product (at the time) made by Bayer. It's a flea collar called Seresto that is sold on Amazon. I couldn't believe that a flea collar would really work. But, after having to hire Orkin to get the fleas out of my home, I was willing to try it. It's the best product that I have used for fleas and ticks. It's easy to use. I just put the collar on my dog. In few days all fleas were gone. The only ticks I ever find on my dog are the ones that he picks up during a walk or bush adventure. They are easily brushed off (when I notice them) and never attach. The collar lasts as long as advertised--8 months or in our case 5 months since he likes to swim. Unlike the drops, he is never lethargic afterwards. I have used several of these Seresto collars now and can't recommend them enough. They are sold on Amazon, by veterinarians, and I've seen them at Pet Smart as well.
S**A
Will always use this for our furnace babies
Our oldest dog is going to be 10 soon and we have used this since we got them and never had a ticket problem. We have had ticks crawling on their fur in places we have camped where they are really bad but never had any latch onto them. They have really thick fur and we dont even notice that it makes their hair greasy or that there is any smell to it either. Works great!
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