*Reactivity: Gibbon, Chimpanzee, Gorilla, Hamster, Human, Monkey, Mouse, Orangutan, Rabbit, Rat Predicted Reactivity: Bat, Dog, Horse, Pig (at least 90% immunogen sequence identity); *Specificity: Human AVPR2. BLAST analysis of the peptide immunogen showed no homology with other human proteins.Target Species: Human; *Immunogen Description: Synthetic 20 amino acid peptide from 3rd cytoplasmic domain of human AVPR2. Percent identity with other species by BLAST analysis: Human, Chimpanzee, Gorilla, Orangutan, Gibbon, Monkey, Marmoset, Mouse, Rat, Hamster, Elephant, Rabbit (100%).; *Immunogen: AVPR2 / V2R antibody was raised against synthetic 20 amino acid peptide from 3rd cytoplasmic domain of human AVPR2. Percent identity with other species by BLAST analysis: Human, Chimpanzee, Gorilla, Orangutan, Gibbon, Monkey, Marmoset, Mouse, Rat, Hamster, Elephant, Rabbit (100%); Baboon, Bat, Horse (95%); Dog, Pig (90%); Armadillo (85%); Shrew, Panda, Bovine (80%).; *Accession#: NP_000045.1; NM_000054.4; P30518; *Description: The human AVPR2 locus encodes vasopressin receptor type 2, a member of the vasopressin/oxytocin family subfamily. V2 receptor has been shown to concentrate the urine and maintain water homeostasis by responding to the pituitary hormone arginine vasopressin (AVP). Loss of gene function results in the disease Nephrogenic Diabetes Insipidus (NDI).; *NCBI Summary: This gene encodes the vasopressin receptor, type 2, also known as the V2 receptor, which belongs to the seven-transmembrane-domain G protein-coupled receptor (GPCR) superfamily, and couples to Gs thus stimulating adenylate cyclase. The subfamily that includes the V2 receptor, the V1a and V1b vasopressin receptors, the oxytocin receptor, and isotocin and mesotocin receptors in non-mammals, is well conserved, though several members signal via other G proteins. All bind similar cyclic nonapeptide hormones. The V2 receptor is expressed in the kidney tubule, predominantly in the distal convoluted tubule ...
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